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Larsucosterol (trimethylamine) is a cholesterol metabolite and a potent liver X receptor (LXR) antagonist. It acts as an endogenous regulator, decreasing lipogenesis and inhibiting cholesterol biosynthesis by reducing mRNA levels and blocking SREBP-1 activation.
Inhibits cholesterol biosynthesis by decreasing HMG-CoA reductase mRNA levels.
Inhibits HMG-CoA reductase expression via SREBP1 activation and expression in hepatocytes.
Increases cell proliferation and decreases apoptosis in macrophages.
Inhibits activation of liver oxysterol receptor LXRα in macrophages.
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APRIL protein (CD256) is a ligand in the tumor necrosis factor (TNF) family that can induce proliferation regulate tumor cell growth and may participate in mononuclear/macrophage-mediated immune process[1] APRIL protein is produced by myeloid cells and their precursors to accelerate cell maturation and peripheral rupture[2] APRIL protein has been widely used in the study of lymphatic malignancies APRIL protein is a type II membrane protein with cytoplasmic domain hydrophobic transmembrane domain and extracellular domain APRIL/TNFSF13 Trimer Protein Cynomolgus (HEK293 His-Flag-Avi) is produced by HEK293 cells (K112-L250) with N-terminal His Avi and Flag tags
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NS 1643 (CAS 448895-37-2) is a small-molecule partial agonist of the human hERG potassium channel exhibiting an EC50 of 10 5 M In murine models of triple-negative breast cancer (TNBC) NS 1643 has been shown to inhibit tumor growth via specific signaling pathways Experimental studies demonstrate that NS 1643 suppresses both migration and invasion of breast cancer cells Due to these properties NS 1643 serves as a valuable tool for investigating hERG channel modulation and its impact on cancer cell behavior with potential applications in preclinical oncology research
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Tetrabutylammonium perchlorate is a quaternary ammonium salt commonly used as an electrolyte, phase-transfer reagent, and perchlorate anion source in organic synthesis and electrochemical applications. Supplied as a high-purity crystalline solid, it is suitable for laboratory research and analytical work.
High purity 98.0% suitable for research applications.
Functions as an electrolyte for electrochemical measurements.
Effective phase-transfer reagent for organic reactions.
Stable solid when stored sealed and away from moisture.
Available in lab-scale pack sizes for bench use.
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Tetrabutylammonium triiodideIt is an organic compound and belongs to the category of quaternary ammonium salts It is a strong oxidizing agent and iodinating reagent often used in organic chemical reactions especially the conversion of alkenes and alkynes to the corresponding diiodide or tetraiodide compounds Tetrabutylammonium triiodideThere are various applications in synthetic organic chemistry especially in the synthesis of natural products pharmaceuticals and specialty chemicals
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